02/19/2003
华盛顿：研究人员称，一种似乎感染了上百万人，而没有引起症状的无害病毒可能有助于减缓致命性艾滋病病毒的进展。
这种被称作为GBV-C的病毒，可能是通过阻挡进入细胞的门户，以防止艾滋病病毒感染细胞，在一个艾滋病专家大会上，研究人员报告，更多的研究可能会发现新的途径来治疗艾滋病--这个感染了全球三千六百万人口的疾病。
在波士顿麻萨诸塞州举行的第十次逆转录病毒和机会性感染大会上，研究人员宣称了一个好消息就是美国的许多HIV感染者似乎感染了GBV-C毒。
国家变态反应和传染性疾病研究院的Dr. Carolyn Williams报告，这个发现可能有助于解释为什么有些人在感染了病毒，十年后仍存活而没有严重的并发症。这是他参与领导的一个研究项目之一。
这些被GBV-C感染的病人虽然最终还会死于艾滋病病毒的感染，但是病情的进展过程要比平均患者长的多。
GBV-C是在1995年发现的，还被称为庚型肝炎，但是这个名字被否定掉了，因为它不同于肝炎病毒，它似乎并不会损伤肝脏。像艾滋病病毒一样，GBV感染了被称为淋巴细胞的免疫细胞。
2001年9月，在爱荷华州大学的一组人员报告说，他们已经在一些HIV感染者的血液中发现了这种病毒，这些病人似乎比正常病人更能持久的抵御艾滋病病毒的侵害。
上星期在逆转录酶病毒大会上，这是每年一次最大的艾滋病医学研究人员的聚会，爱荷华州的一组研究人员和国家变态反应和传染性疾病研究院的另外一组研究人员证实了这种影响。
"我们发现GBV-C持续阳性的人群可能要多生存2.5倍的时间。"研究院的Williams告诉记者。
他们观察了271名HIV感染者的血液，这是他们第一次就诊时的血液，11年后，GBV-C持续感染的人群中75%的人一直存活，与此对比，从未感染过GBV的人群中只有39%存活。
"持续"这个词是很重要的，因为在机体清除GB病毒的12个人中，只有16%的人存活了11年以上。
迪赛诺生物医药有限公司 王玥译 地坛医院 曹传梅校
摘自：Beijing Weekend
02/19/2003
Harmless virus may slow AIDS progress
02/19/2003
WASHINGTON: A harmless virus that seems to infect millions of people without causing symptoms may help slow the deadly progress of the AIDS virus, researchers said.
The virus, called GBV-C, may block one of the cellular doorways used by the AIDS virus to infect cells, researchers told a meeting of HIV experts. More studies may lead to new ways to treat AIDS, which infects 36 million people worldwide.
The good news is that many HIV patients in the United States seem to be infected with the GBV-C virus, the researchers told the 10th annual Conference on Retroviruses and Opportunistic Infections being held in Boston, Massachusetts.
The findings may help explain why some people survive for decades without serious complications from the virus, said Dr Carolyn Williams of the National Institute of Allergy and Infectious Diseases, who helped lead one of the studies.
Such patients eventually succumb to the virus but the process takes much longer than for the average patient.
Researchers discovered GBV-C in 1995. They also called it hepatitis G but that name has been dropped because, unlike hepatitis viruses, this one does not seem to damage the liver. Like the AIDS virus, GBV infects immune-system cells called lymphocytes.
In September 2001, a team at the University of Iowa reported they had found the virus in the blood of HIV patients, and said these patients seemed to resist the ravages of AIDS for longer than normal.
Last week at the retrovirus meeting, the largest annual gathering of AIDS medical researchers, the Iowa team and another group headed by the National Institute of Allergy and Infectious Diseases confirmed the effect.
"We found that men who were persistently positive for GBV-C were 2.5 times more likely to survive," the institute"s Williams told reporters.
They looked at blood taken from 271 HIV patients when they first visited a doctor. Eleven years later, 75 per cent of the men who had persistent GBV-C infections were still alive, compared to 39 per cent of those who had never been infected with GBV.
The word "persistent" is important, because there were 12 men whose bodies had cleared the GB virus and, of them, only 16 per cent were alive 11 years later.
Agencies via Xinhua
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